2 research outputs found
The effect of open lung ventilation on right ventricular and left ventricular function in lung-lavaged pigs
INTRODUCTION: Ventilation according to the open lung concept (OLC)
consists of recruitment maneuvers, followed by low tidal volume and high
positive end-expiratory pressure, aiming at minimizing atelectasis. The
minimization of atelectasis reduces the right ventricular (RV) afterload,
but the increased intrathoracic pressures used by OLC ventilation could
increase the RV afterload. We hypothesize that when atelectasis is
minimized by OLC ventilation, cardiac function is not affected despite the
higher mean airway pressure. METHODS: After repeated lung lavage, each pig
(n = 10) was conventionally ventilated and was ventilated according to OLC
in a randomized cross-over setting. Conventional mechanical ventilation
(CMV) consisted of volume-controlled ventilation with 5 cmH2O positive
end-expiratory pressure and a tidal volume of 8-10 ml/kg. No recruitment
maneuvers were performed. During OLC ventilation, recruitment maneuvers
were applied until PaO2/FiO2 > 60 kPa. The peak inspiratory pressure was
set to obtain a tidal volume of 6-8 ml/kg. The cardiac output (CO), th